Name | Stilbamidine |
Synonyms | Ba 2652 Stilbamidin STILBAMIDINE stilbamidine Stilbamidine 4,4'-Stilbenedicarboxamidine 2-(2-phenylethenyl)benzenecarboximidamide Benzenecarboximidamide, 4,4'-(1,2-ethenediyl)bis- |
CAS | 122-06-5 |
EINECS | 2045195 |
Molecular Formula | C16H16N4 |
Molar Mass | 264.33 |
Density | 1.1536 (rough estimate) |
Boling Point | 397.56°C (rough estimate) |
Solubility | DMSO |
Storage Condition | -20℃ |
Refractive Index | 1.6000 (estimate) |
In vitro study | The high-affinity pentamidine transporter (HAPT1) is inhibited by Propamidine but displays only low affinity to Stilbamidine. adenosine-sensitive pentamidine transporter (ASPT1), in contrast, is strongly inhibited by Stilbamidine, and Propamidine. [ 3 H]pentamidine uptake is determined in the presence of various concentrations of adenosine (IC 50 =1.2 μM) or melarsen oxide (IC 50 =0.7 μM), as well as in the presence of 250 μM adenosine and increasing concentrations of hypoxanthine, Propamidine (IC 50 =6.1 μM) and Stilbamidine (IC 50 =110 μM). The two diamidine compounds, Stilbamidine and Pentamidine are used to treat in multiple myeloma, a disease in which increase of the globulin content of the serum is of frequent occurrence. |